Vaterian Cancer in Siblings

APPARENT MINERALOCORTICOID EXCESS IN THREE SIBLINGS

Three siblings (1 boy, 2 girls) with hypertension and hypokalemia are presented, two with low plasma aldosterone and suppressed renin activity and the eldest with a high renin and aldosterone level due to secondary changes in her kidneys. Urinary tetrahydrocortisol (THF) was increased relative to tetrahydrocortisone (THE). Cortisol ring A reduction constant was also lower than normal. Thes...

Anthracycline-induced cardiomyopathy in siblings with early breast cancer.

A 41-year-old woman with no significant previous medical or family history underwent a left wide local excision (WLE) and axillary node clearance for a 9-mm grade 3 IDC, node-negative breast cancer. The tumour was estrogen receptor (ER), progesterone receptor (PgR) and HER-2 negative. She received six cycles of adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC 75, ...

Alexithymia in children with cancer and their siblings.

OBJECTIVE The purpose of this study was to examine the levels of alexithymia in children with cancer, in siblings of children with cancer, and in healthy controls. METHOD In order to compare the groups the Alexithymia Questionnaire for Children was used. The study group consisted of 97 children with cancer, 95 siblings, and 151 healthy controls. RESULTS The highest level of alexithymia was ...

Wnt and Kras signaling-dark siblings in lung cancer

Aberrant Kras signaling is observed in a high percentage of human lung cancers while activating mutations in the Wnt/b-catenin signaling pathway are only rarely found. Our recent work has shown that the combined activation of both Kras and Wnt/b-catenin signaling leads to a dramatic increase in both tumor incidence and size. Moreover, lung tumors generated by the combined activation of both of ...

Siblings of Pediatric Cancer Patients: Stress and Psychological Outcomes